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Proteomics · Molecular Chaperone — Salivary Analysis

Heat shock cognate 71 kDa protein

Heat shock cognate 71 kDa protein (HSC70/HSPA8) is a constitutively expressed member of the HSP70 chaperone family that maintains protein folding, mediates chaperone-assisted autophagy, and stabilises the proteome under mechanical and metabolic stress. Its salivary appearance reflects the cellular stress-response load imposed by training. Wenzel et al. (2026) identified HSC70 among the salivary proteins that reliably distinguish recent exercise in a multi-omics strain model.

References

  1. Targeted saliva multi-omics is a reliable, non-invasive method to capture physiological stress and recoveryWenzel C, Kalaycik B, … Zimmer P. · TU Dortmund University · 2026
  2. The exercise-induced stress response of skeletal muscle, with specific emphasis on humansMorton JP et al. · Sports Med · 2009 — PubMed